45-year-old pregnant women can avoid fetal malformation through strict and punctual labor and delivery examination, punctual and malformation examination, strengthen nutrition and other methods. 1. Strictly on time maternity examination: 45-year-old pregnant women are already pregnant women of advanced age, belonging to the high-risk pregnancy, increased the occurrence of fetal malformation, pregnancy complications or complications and other risks, pregnancy must comply with the doctor’s orders on time maternity examination, reasonable and standardized maternity examination can be found as early as possible fetal anomalies, which can reduce the incidence of birth defects. 2. On time for malformation checkups: malformation checkups during pregnancy have strict gestational week requirements, and should be conducted in strict compliance with the doctor’s instructions, such as NT (fetal nuchal translucency) measurement at 11-13+6 weeks of pregnancy, amniocentesis at 16-22 weeks of pregnancy, and ultrasound screening of the fetal system structure at 20-24 weeks of pregnancy, and so on. 3. Enhance nutrition: During pregnancy, it is necessary to ensure a nutritionally balanced diet, reasonable intake of diversified foods containing protein, vitamins, minerals, carbohydrates, fats and other nutrients, which can meet the growth and development of the fetus and the physiological needs of the pregnant woman herself. Clinically, when abnormal manifestations occur during pregnancy, it is necessary to actively consult the doctor and follow the doctor’s instructions for reasonable treatment.