High white blood cells and immature granulocytes may be related to acute blood loss, infection, leukemia, etc., as follows. 1. Acute blood loss: when the blood volume in the body drops sharply, it will stimulate the hematopoietic cells in the bone marrow, which will cause the leukocyte reactivity to increase, mainly the immature granulocytes increase. 2. Infection: when the body is infected, the stimulation of pathogenic microorganisms leads to the early release of immature granulocytes in the bone marrow, resulting in a high immature granulocyte ratio. In addition, it also stimulates the release of leukocytes to play an immune role. 3. Leukemia: mainly due to uncontrolled cell proliferation and differentiation disorders, if the body has abnormally high leukocytes and immature granulocytes, we need to be alert to leukemia. Increased white blood cell and immature granulocyte ratio may also be other conditions, it is recommended to consult a doctor in a timely manner to identify the cause of the disease, and comply with the doctor’s instructions for treatment.