Small white spots on the calves generally does not matter, it may be due to vitiligo, senile white spots and other reasons. 1. Vitiligo: It is mainly a skin disease caused by the destruction of subcutaneous melanocytes, which will cause the skin to have white patches of varying sizes, smooth surface and clear boundaries. It can be treated with topical glucocorticoids, calcium-modulated phosphatase inhibitors and other drugs under the guidance of a doctor. 2. Age-related white spots: with age, skin aging may cause the skin to have pinhead to mung bean size, round white spots, resulting in the phenomenon of small white spots on the calf, usually without special treatment. It is recommended that patients with small white spots on the calf should go to regular hospitals in time to get a clear diagnosis and take treatment measures under the guidance of doctors.