Hepatitis B virus DNA turning negative indicates that the viral load has significantly decreased and is within the detection range. Hepatitis B virus DNA, the test if negative, indicating that the body contains a relatively low number of viruses, the specific need to assess the reference range according to different test kits, less than the reference range below is negative, but it does not mean that the body does not have the virus, it can only indicate that the infectiousness of the obvious decline. Hepatitis B virus DNA is a quantitative indicator of the replication of the hepatitis B virus in the body, which can be a better understanding of whether or not there is a reproduction of the hepatitis B virus in the body, which is a very key indicator for guiding anti-disease treatment, and if it turns negative, it means that the effect of antiviral treatment is more satisfactory, and it is necessary to continue to maintain the treatment. Hepatitis B is an infectious disease, according to the quantitative situation of the virus, you can judge the strength of the infectiousness, negative viral load infectiousness is relatively low, if the viral load is higher, often suggests that the infectiousness is also stronger, it is recommended that the hepatitis B vaccine, to prevent the transmission of the hepatitis B virus.