Reynaud’s disease can be clinically treated with vascular smooth muscle relaxing drugs, such as niacin, with 50-200mg, 3-4 times daily, orally. Risperdal 0.25mg, 2-3 times daily, orally. Calcium blockers, thiodiazepine 30mg, 3 times daily, orally. Vitamins, vitamin B1, 200mg, 3 times daily, orally. Alpha-blockers, such as toltrazurin hydrochloride 25mg, 3 times daily, orally, are also available. For local treatment, a 2% nitroglycerin ointment can be applied locally to the finger, or a sealant therapy can be used. For superficial ulcers at the tip of the finger, a 0.5% neomycin solution or ointment can be applied topically. Surgical treatment is mainly for more serious conditions, with obvious neurological factors causing nutritional changes in the skin, and the effect of internal medication is not obvious, you can consider doing the corresponding sympathectomy.