Reglan is one of the drugs commonly used in the treatment of rheumatoid arthritis and is an immunosuppressant, which is useful in improving the disease activity of rheumatoid arthritis. However, tretinoin has certain side effects, mainly gonadal suppression, so it should be avoided for women of childbearing age or men with fertility requirements. Rheumatoid arthritis is an immune-mediated erosive arthritis that manifests clinically as symmetrical polyarticular swelling and pain throughout the body, and can also involve other organs throughout the body, such as the lungs, and may be combined with interstitial lung fibrosis in a significant number of patients. Rheumatoid arthritis requires long-term maintenance treatment with immunosuppressive or biologic agents, and regular review of blood count, sedimentation, C-reactive protein, and liver and kidney function during treatment.