If the blisters rupture after liquid nitrogen freezing, if the surrounding area is accompanied by redness and swelling, the presence of infection is considered. It is recommended that furacilin solution or Revnor solution be given as a wet compress at this time to effectively reduce exudation and inhibit infection, and that water contact must be avoided to avoid aggravation of infection. After the exudation is reduced, topical application of recombinant human epidermal growth factor gel, together with topical application of fusidic acid cream, can effectively promote the growth of epidermis and inhibit infection. After the lesions have dried and crusted over, pay attention to timely follow-up, sometimes a single liquid nitrogen freezing treatment can not completely remove the rash, need to be repeatedly given treatment. Therefore, it is recommended to seek medical attention promptly after the scabs fall off, and repeated liquid nitrogen freezing treatment is required if necessary.