Chronic hepatitis B may lead to cirrhosis, primary liver cancer, liver failure and other terrible consequences if treatment is neglected for a long time. However, if active review is carried out and comprehensive treatment such as antiviral and antifibrotic therapy is taken in time if necessary, some patients can achieve clinical cure, so it is not advisable to be overly alarmed. Chronic hepatitis B patients may have obvious liver function abnormalities and clinical symptoms, such as nausea, poor appetite, fatigue, discomfort in the liver area, and so on, and the prognosis is generally good for those who are mild. Active antiviral treatment can help inhibit the gene replication of hepatitis B virus, reduce the inflammatory necrosis of hepatocytes and liver fibrosis, and delay further deterioration of the disease, and some patients can achieve clinical cure and return to normal work and life. However, if chronic hepatitis B is diagnosed and treatment is neglected for a long time, it may accelerate intra- and extra-hepatic damage and cause liver failure, etc. Most liver cancers occur in the late stage of hepatitis B virus infection, especially on the basis of cirrhosis, which may eventually lead to death. Chronic hepatitis B patients should set up a correct view of the disease, actively treat under medical advice, and at the same time have patience and confidence in hepatitis treatment. Daily attention to high nutrition, easy to digest diet, avoid alcohol, regular review.