After you have had heart surgery to resume normal diet and habits, you should pay attention to the following points: 1. The influence of diet: the patient’s postoperative diet can interfere with the anticoagulant effect of coumarin-based drugs. Those who often eat larger amounts of vegetables such as spinach, bok choy, alfalfa, cabbage, tomatoes, cauliflower, fresh peas, or often eat more meat, such as pork liver or fruit, because these foods contain more vitamin K, which can shorten the PT value. 1) After discharge from the hospital, the diet is generally not restricted, and the diet can be improved and the variety of food changed, but do not monotonously eat a certain kind of vegetable containing more vitamin K for a long time, and of course there is no need to change the habit of eating vegetables. Song Zhigang, Department of Thoracic Surgery, Shanghai Changhai Hospital 2) When eating vegetables with high vitamin K content and diet significantly increase or decrease in a short period of time, PT should be rechecked and adjusted according to the results. 3)Drinking alcohol can affect the metabolism of warfarin, so during the anticoagulation period, then try not to drink alcohol, let alone alcohol. 2, the influence of drugs: coumarin anticoagulants are susceptible to the influence of other drugs, some increase, some weaken, or even offset the anticoagulant effect. Drugs that enhance the effect of Warfarin include: alcohol, cimetidine, steroids, fenbid, anti-inflammatory pain, quinidine, salicylate, methotrexate, sulfonamide, botrytisol, high-dose gentamicin, thyroxine, chloral hydrate, etc. Drugs that weaken the effect of warfarin are: vitamin K, sleeping pills, estrogen, oral contraceptives, rifampicin, abbreviated bile amines, barbiturates, etc. The above drugs should be used with caution, or taken under the guidance of a doctor or indiscriminate PT testing. If there are significant interfering effects should be avoided, such as vitamin K, etc. Some alternative drugs are available, such as replacing other sleeping pills with An regularly. Need long-term use of female contraceptives, PT can be tested at the beginning of the drug to determine whether to increase the amount of anticoagulant. If a short-term increase in a certain drug, such as cold medicine, temporary injection of antibiotics for a few days, it is not necessary to adjust the medication, generally not to interfere greatly. 3, the influence of disease and illness factors: there are steatorrhea, biliary obstruction, starvation, acute viral hepatitis, hyperthyroidism, post-surgical infection, hyperthermia and other diseases can make vitamin K absorption decline, while the anticoagulant effect of Warfarin is enhanced. In patients with congestive heart failure, hepatomegaly, poor liver function or ascites, the sensitivity to anticoagulants is enhanced due to impaired production of coagulation factors by the liver, so attention should be paid to laboratory tests for PT and adjustment of coagulant dose. Patients with myocardial infarction and pulmonary embolism have low tolerance to oral anticoagulant therapy, and PT is prolonged quickly. In addition, the anticoagulant effect of Warfarin can be affected by factors such as moisture, spoilage, mold, vomiting and diarrhea.