Insulin Growth Factor Binding Protein Test Strips to detect premature rupture of amniotic fluid is not always accurate, there are some false positives. Insulin growth factor binding protein 1 is a unique indicator of amniotic fluid, the use of insulin growth factor binding protein test paper to detect whether the amniotic fluid rupture, need to be combined with other symptoms of comprehensive judgment. 1. Not amniotic fluid rupture: If the test sample is contaminated by blood, urine, or cervical mucus when pregnant women take the test, false positives will occur, and if the pregnant woman does not have any other uncomfortable symptoms at this time, most of them are not amniotic fluid rupture. 2. Amniotic fluid rupture: normal vaginal fluid pH <4.5, if insulin growth factor binding protein is positive, and vaginal fluid pH test paper >6.5, or vaginal fluid smear microscopy to see amniotic tooth-like crystals, and pregnant women self-conscious urine-like liquid flow, can be diagnosed with amniotic fluid rupture. In addition, timely obstetric examination is needed during pregnancy, and if there is any abnormality, it is recommended to consult a doctor for examination in time to avoid delaying the condition.