Since the introduction of the first generation of antidepressant drugs isoproterenol and promethazine in the 1950s, a total of 39 antidepressant drugs are currently in clinical use. Their efficacy in treating depression is comparable (except venlafaxine), the main differences are the ease of use, the size of side effects, the speed of onset of action, the price and certain pharmacological properties of the drugs, and these differences create a certain antidepressant more suitable for treating a certain type of depression than others. I. Treatment of depression with marked agitation Patients with depression can be accompanied by marked agitation, while agitation is also a feature of perimenopausal depression in women. In the treatment, antidepressants with sedative effect can be considered, in the order of venlafaxine, mirtazapine, paroxetine, fluvoxamine, citalopram and amitriptyline. In the early stage of treatment, small doses of alprazolam or lorazepam can be considered in combination. Second, the treatment of depression with obsessive-compulsive symptoms Patients with depression can be accompanied by obsessive-compulsive symptoms, and patients with obsessive-compulsive disorder can also be accompanied by depression, and the two affect each other. It is generally believed that depression with obsessive-compulsive symptoms is more difficult to treat than simple depression, if you want to achieve better results, the use of antidepressants must be anti-compulsive effect (FAD approved drugs for the treatment of obsessive-compulsive disorder: chlorpromazine, fluvoxamine, paroxetine, sertraline, fluoxetine), followed by antidepressants with obsessive-compulsive symptoms of depression treatment The dosage is 2-4 times the dosage for the treatment of simple depression, and the treatment time is longer . Antidepressants are used in large quantities and for a long time, so domestic antidepressants have a great advantage. Third, the treatment of depression with psychotic symptoms Generally speaking, this patient not only has the symptoms of depression, but also has psychotic symptoms such as hallucinations, delusions, and positive thinking disorder, but does not meet the diagnosis of schizophrenia, antidepressants and antipsychotics should be used as above, and the two drugs should be treated in full amount and in full course, respectively. IV. Treatment of depression with psychomotor retardation Patients with retarded depression are psychologically characterized by a delay in the initiation of thought and a slow flow of thought, highlighted by the lack of vitality and biological symptoms dominated by sleep disturbances and reduced appetite. Therefore, antidepressants with strong activating and weak sedative effects can be considered in the treatment, in the order of fluoxetine, sertraline, paroxetine, citalopram, etc.