According to the latest national guidelines for the prevention and treatment of hepatitis B, there are two very effective methods of prevention: The first method: newborns of HBsAg-positive mothers should be injected with hepatitis B immune globulin as early as possible in the first 24 hours of life (preferably within the first 12 hours of life) at a dose of more than 100 IU, and at the same time, they should be inoculated with either 10ug of recombinant yeast or 20ug of Chinese hamster oocyte at different sites. Hepatitis B vaccine, and the 2nd and 3rd doses of Hepatitis B vaccine at 1 month and 6 months of age, respectively. The second method: 1 injection of hepatitis B immunoglobulin within 12 hours of birth, followed by a 2nd injection of hepatitis B immunoglobulin 1 month later, and 1 injection of 10ug recombinant yeast or 20ug Chinese hamster oocyte hepatitis B vaccine at different sites at the same time, and 2nd and 3rd injections of hepatitis B vaccine at intervals of 1 month and 6 months, respectively. Newborns were allowed to receive breastfeeding from HBsAg-positive mothers after receiving hepatitis B immune globulin and hepatitis B vaccine within 12 hours of birth.