Serum and plasma are both liquid parts of blood, but they have distinct differences. Plasma is the part of blood that remains after all blood cells are separated from the whole blood, that is, the red blood cells, white blood cells and platelets are separated from the whole blood and the remaining yellow liquid part is plasma. Plasma includes various clotting factors, various ions, albumin, globulin, and coagulation factors, etc. Serum is the colorless and transparent liquid formed after blood clotting. Compared with plasma, serum has less clotting factors involved in the clotting pathway because in the clotting process, clotting factors are involved in the formation of clots, so compared with plasma, serum lacks clotting factors, but other components, including various ions, albumin and globulin, are the same as plasma components. It is the same as plasma.