Irbesartan hydrochlorothiazide tablets is a compound preparation of Irbesartan and hydrochlorothiazide, hydrogen which chlorothiazide belongs to the diuretic, its mechanism of action is to inhibit the reabsorption of sodium ions, for patients with essential hypertension, contraindications for allergy, anuria and so on. 1. Mechanism of action: Irbesartan hydrochlorothiazide tablets is a combination of Irbesartan and hydrochlorothiazide, Irbesartan belongs to the angiotensin II receptor antagonist, hydrochlorothiazide belongs to the thiazide diuretics. Hydrochlorothiazide acts on the distal part of the ascending branch of the renal distal tubule and medullary collaterals to inhibit the reabsorption of sodium ions and play a diuretic role. 2. Indications: for patients with essential hypertension. 3. Contraindications: including allergy, anuria, use of aliskiren, etc.. (1) Patients who are allergic to any component of Irbesartan Hydrochlorothiazide Tablets. (2) Contraindicated in patients with anuria or allergy to other sulfonamides. (3) Concomitant use of Aliskiren and Irbesartan Hydrochlorothiazide Tablets is prohibited in patients with diabetes. Patients should not use Irbesartan Hydrochlorothiazide Tablets on their own, and should standardize the use of medication under the guidance of a doctor.