Long-term use of antihypertensive drugs has some potential effects on sexual life. Drugs that may affect libido, such as methyldopa, colistin, propranolol, hydrazin, and reserpine; drugs that may affect erection, such as methyldopa, colistin, propranolol, hydrazin, and thiazide diuretics; and drugs that may affect ejaculation, such as methyldopa, phenobarbital, and guanethidine. In addition, other drugs that may affect erectile dysfunction include drugs that act on the central nervous system, such as some hypnotic sedatives, anxiolytics amphetamines, Librium, etc.; hormonal drugs, such as adrenocorticotropic hormones, prednisones, estrogens, etc. If sexual disorders do occur due to the application of these drugs, it is recommended to promptly communicate with your doctor if there are viable alternative treatment options.