The American Cancer Society in 2009 expects the number of new cases of pancreatic cancer in Americans to reach 42,470 and the number of new deaths to reach 35,240. Worldwide, from 2000 to 2009, the incidence and mortality rate of pancreatic cancer has been on the rise year by year. The 5-year survival rate of pancreatic cancer is only about 0-5%, which has been kept as the lowest record among all kinds of cancers being counted. The prognosis of pancreatic cancer is poor, most patients are already in advanced stage when they are diagnosed, and the proportion of stage III and IV can be as high as 70%, and only about 20% of patients can be treated surgically. It is mainly related to the difficulty of early diagnosis and low surgical resection rate. To improve the early diagnosis rate of pancreatic cancer, we need to: 1. increase the awareness of pancreatic cancer among all people; 2. increase the screening of high-risk groups. The application of high-resolution CT, ultrasound endoscopy and PET-CT has enabled more and more high-risk groups or suspected patients to be diagnosed correctly, and the accurate staging of CT can further establish the treatment plan and judge the prognosis; 3. Surgical resection is still the main treatment for pancreatic cancer. The factors affecting the survival rate of pancreatic cancer after radical surgery are many, and local recurrence is one of the important influencing factors. In advanced unresectable cases, comprehensive treatment is important, among which chemotherapy is the main adjuvant treatment. Currently, gemcitabine has been used as the first line of chemotherapy for pancreatic cancer both internationally and domestically. Molecular targeted drug therapy has become a hot spot and a new hope for pancreatic cancer treatment, mainly including vascular endothelial growth factor inhibitors, epidermal growth factor inhibitors, epoxygenase-2 inhibitors and so on. When the clinical diagnosis of pancreatic cancer is established, do not rush to the doctor. Seek out excellent clinical experts in the specialty, listen carefully to their analysis of individual patient’s disease, disease stage, systemic condition and his recommended treatment method, and then make treatment plans and decisions based on the level of family support and financial status.