Rectal cancer metastasis to mesenteric lymph nodes should be specifically analyzed whether it can be cured or not according to the scope and number of metastasis. If the lesion is mild, there is hope for cure; if it is serious, the cure rate is low. According to pathological staging, for ulcerative, invasive rectal cancer, as well as impression cell carcinoma, mucinous adenocarcinoma, undifferentiated carcinoma and so on with high malignancy and poor prognosis, it is difficult to be cured if it metastasizes to mesenteric lymph. When rectal cancer metastasizes to mesenteric lymph nodes, if the primary lesion is small, as long as it actively cooperates with surgical treatment, the primary lesion is removed and the diseased lymph nodes are cleared. After surgery, chemotherapy (5-FU, cisplatin, etc.), radiotherapy, traditional Chinese medicine treatment and targeted therapy can have good therapeutic effect, and the hope of cure is very great. Drugs should be applied under the guidance of doctors. If the patient has already had most of the lymph node metastases, this time means that the patient is already in the advanced stage and the condition is very serious. In this case, it is recommended to receive radiotherapy first, with good results and then surgery, but the hope to achieve a cure is relatively small. In addition to surgery and radiotherapy, the patient can be treated with traditional Chinese medicine at the same time to improve his physical condition and prolong his life.