Pustules on the face can rupture when squeezed, resulting in white material and blood. Consider acne, folliculitis, or boils on the face, and try to avoid squeezing with your hands to prevent infections from occurring. Inflammatory papules and small pustules can form on the face due to the high secretion of sebaceous glands from hair follicles and the growth and infection of microorganisms such as bacteria and fungi in the hair follicles, which can lead to acne, folliculitis or boils. When the pustules gradually increase in size and form pus plugs, pus and blood secretions can be squeezed out. If there is secondary infection, scarring may remain on the face after healing. In addition, when squeezing the pus plugs located in the nose, upper lip and the surrounding danger triangle, there is a possibility of triggering intracranial infection. To summarize, avoid squeezing when pus plugs appear on the face to prevent serious consequences. You can go to a hospital specialist and follow the doctor’s instructions.