Hepatitis B vaccine should not be given to patients with hepatitis and fever, acute infectious diseases, patients with serious chronic diseases, people with immunodeficiency, people with severe allergies and people who are using immunosuppressive drugs. People with serum disease, bronchial asthma, allergic urticaria and allergy to some drugs such as penicillin and sulfonamide are prohibited. Hepatitis B vaccination is temporarily contraindicated for newborns born abnormally at low birth weight, premature birth, and caesarean section. Although hepatitis B vaccine is not harmful to these newborns, it is better to postpone the vaccination because their own physical condition is prone to coupling events.