Not drinking water for a long period of time is more likely to lead to thrombotic diseases, kidney stones, urinary tract infections, and kidney function impairment. 1. Thrombophilia: not drinking water for a long period of time will lead to dehydration, increased blood concentration and slowed blood flow, increasing the risk of thrombophilia. 2. Kidney stones: if you don’t drink water for a long time, it will lead to reduced urination, localized crystal deposition in the renal collecting system, and with the development of time, it will be easier to form kidney stones, which may cause hydronephrosis, secondary renal insufficiency, and cause serious impacts on patients. 3. Urinary tract infection: long-term non-drinking of water leads to reduced urination, the self-cleaning effect of the urinary system urinary flushing can not play a full role, bacteria are more likely to reproduce in the urinary tract, and ultimately cause urinary tract infection. 4. Kidney function injury: long-term not drinking water may also cause insufficient perfusion of the kidneys, there is a rapid increase in blood creatinine, urea nitrogen, which can easily lead to acute kidney injury, resulting in a relatively large damage to the body. Regular supplementation of water is beneficial to the body to dilute the blood, thereby improving the metabolic function and increasing the amount of urination to effectively discharge harmful substances from the body, so you should properly increase the amount of water to drink in your life.