Cerebral white matter degeneration is an imaging term that refers to the high bright signal of cerebral white matter on T2 sequence or FLAIR sequence when doing MRI. There are various causes of cerebral white matter degeneration, including genetic factors, vascular risk factors, and disease factors, as follows: First, genetic factors: many genetic cerebral white matter lesions can lead to cerebral white matter degeneration. Second, vascular risk factors: such as hypertension, diabetes mellitus, hyperlipidemia, can lead to insufficient blood supply and poor microcirculation in the white matter of the brain, which can lead to cerebral white matter degeneration. Third, disease factors: such as autoimmune diseases, multiple sclerosis, and encephalitis, carbon monoxide poisoning, etc., can also induce cerebral white matter degeneration.