Adefovir-induced osteochondrosis with hypophosphatemia. How is it determined and detected in time? First of all this adverse reaction appears about 3 years after taking the drug and was first reported after 1.5 years. It manifests as skeletal pain, limited mobility, shortened height, and muscle weakness. The bone pain is mainly in the extremities and sternum. Then there is taking the drug at the same time the above symptoms to timely liver disease clinic follow-up, laboratory tests can be seen in the blood phosphorus reduction, urine abnormalities and other manifestations. Then whether adefovir is not safe to use. It is not. 1, can be found with bone pain, muscle weakness and other discomfort. Timely outpatient follow up and blood and urine check can get confirmed diagnosis. 2, appear about 3 years after taking the drug, regular testing can be found. 3.The damage is reversible and can be fully recovered 4-24 weeks after stopping the drug. Discontinuation of adefovir can be replaced with entecavir. 4, there are drugs can be treated, given supplemental phosphorus salts, calcium supplementation to recover well. Therefore, patients taking this drug do not need to stop immediately, regular testing of renal function blood phosphorus can be. What’s more, they should not lose their own antiviral drugs due to small losses, resulting in the progression to cirrhosis or even liver failure.