The lack of smoothness of the gallbladder wall is considered to be related to cholecystitis, which may manifest as nausea, abdominal pain, diarrhea and other gastrointestinal symptoms. Usually, ultrasound will indicate that the wall of the gallbladder is not smooth, which means that the surface of the gallbladder wall is rough, and it is usually considered to be related to the occurrence of cholecystitis, which will be manifested by nausea, abdominal pain, diarrhea, indigestion, loss of appetite and so on. Usually, if there is sudden distension and pain in the right upper abdomen after eating a fatty diet, and other factors have been excluded, and the ultrasound suggests that the wall of the gallbladder is not smooth and rough, this is usually considered to be acute cholecystitis, which requires active anti-inflammatory treatment. If there is a history of pain in the right upper abdomen, and the pain is aggravated after eating, this is considered chronic cholecystitis, and can be treated with drugs such as cefixime, and surgery is recommended if there is no relief. When the wall of the gallbladder is not smooth, it is recommended to standardize the treatment under the guidance of a doctor to avoid delaying the condition.