Five-year survival rate is generally used to judge the survival rate of patients. Patients with advanced colon cancer have a lower five-year survival rate than those with early colon cancer, only about 8 to 10%, because the tumor has metastasized to other adjacent organs or distant metastases. The five-year survival rate of locally progressive stage II to stage III colon cancer patients is 50% to 78% after surgery, chemotherapy and other treatments. In advanced stage colon cancer, the tumor tissue may have metastasized to tissues and organs such as liver, lung, brain, bone, etc., or distant metastasis of lymph nodes or abdominal implantation metastasis may occur, which may be inoperable and need to be treated with radiotherapy, chemotherapy or targeted therapy, which is more difficult to be completely cured and has a lower five-year survival rate. Patients diagnosed with advanced colon cancer should actively cooperate with doctors for treatment and maintain a good mindset and healthy lifestyle, which can help improve the prognosis.