Gastroscopy provides a direct and clear view of lesions in the upper gastrointestinal tract organs such as the esophagus, stomach, and duodenum. However, in the past, patients often neglected to have their digestive system examined because they could not bear the pain of having a gastroscopy. The painless gastroscopy technique uses drug intravenous anesthesia to allow patients to undergo gastroscopy while they sleep. Painless gastroscopy is a technique that is painless to the patient during operation and can avoid mechanical damage caused by involuntary agitation due to pain, which is especially suitable for patients with gastrointestinal diseases who are afraid to undergo examination due to psychological tension. Our hospital has performed painless gastroscopy in more than a thousand cases without any complications.