Method: The drug composition of the formula: 30 grams of raw rhubarb, 5 grams of black sophora, 5 grams of fine spice, 30 grams of calcined oyster, 10 grams of zedoary, 10 grams of cinnamon stick, 30 grams of dandelion, 30 grams of acacia flowers, 30 grams of June snow, etc. boil 200 ml of water once a day to retain enema or colon dialysis, 15 days as a course of treatment. Indications: Early and middle stage of chronic renal insufficiency, and those who do not receive hemodialysis treatment in the late stage. Effect: To pass the internal organs and lower the turbidity, and delay the process of renal decompensation. Principle: Chinese medicine enema and colon dialysis method is to infuse Chinese medicine into the human colon cavity and use the potential absorption and excretion function of the colon to remove harmful metabolites and toxins from the colon and intestinal mucosa, so as to establish the treatment system of “reducing blood creatinine, urea nitrogen, blood uric acid and regulating water and electrolyte balance”. In order to achieve the purpose of “non-dialysis therapy” treatment.