The inactivated EV71 vaccine is not a clinical drug and does not play a therapeutic role, but standardized vaccination with this vaccine can help prevent HFMD caused by EV71 infection. There are many types of enteroviruses that can cause HFMD, and EV71 is one of the most common types. Vaccination with inactivated EV71 vaccine can stimulate the body to develop anti-EV71 immunity for the prevention of HFMD caused by EV71 infection, and is suitable for susceptible EV71 patients between 6 months and 3 years of age. Adverse reactions such as fever, hardness, itching, diarrhea, nausea and vomiting may occur after vaccination. It is contraindicated for those who are allergic to the components of the vaccine, those who are in the period of fever and acute illness, and those who are in the period of acute onset of chronic diseases. However, EV71 inactivated vaccine cannot prevent HFMD caused by other enteroviral infections, such as coxsackievirus group A type 16, etc., and 100% protection cannot be guaranteed after vaccination. Therefore, good hygienic habits, such as washing hands frequently, ventilating often, wearing masks when going out, and using public spoons and chopsticks, are more helpful in the prevention of HFMD.