Crooked corners of the mouth may be due to facial neuritis, stroke and other causes, different causes, different treatments. 1. Facial neuritis: Facial neuritis is also called Bell’s palsy, which is a disease caused by Neurophilic Virus infection, and clinically it can show a series of symptoms of facial nerve paralysis, such as paralysis of the expression muscles on the affected side, crooked corners of the mouth, salivation, disappearance of frontal lines, and inability to close eye cracks. Glucocorticoids such as dexamethasone, antiviral drugs such as acyclovir and ribavirin, and neurotrophic agents such as B vitamins can be given as treatment. 2. Stroke: patients with cerebral hemorrhage and cerebral infarction can also have the manifestations of tilted mouth and limited movement of one side of the limbs, but the treatments of the two are different. Patients with cerebral hemorrhage can be treated with nifedipine to lower blood pressure and mannitol to lower cranial pressure. Patients with cerebral infarction can be treated with recombinant tissue-type fibrinogen activator thrombolysis, aspirin and clopidogrel for antiplatelet aggregation, simvastatin for lowering blood lipids, and edaravone and cytarabine for neuroprotection. In addition to the above factors, the skewed corners of the mouth may also be caused by other diseases, it is recommended to seek medical attention as soon as possible, to the regular hospital to identify the causes, so as to avoid delaying the condition, the use of drugs need to comply with medical advice.