Pulmonary aspergillosis generally refers to pulmonary aspergillosis, which is not effective after taking itraconazole and coughing up blood repeatedly, which is mostly related to factors such as insufficient drug dosage or course of treatment, whether the drug is symptomatic or not, and whether new infections appear. For different situations to take appropriate treatment. 1. Insufficient drug dosage or course of treatment: for example, invasive pulmonary aspergillosis, the dosage is relatively large and the course of treatment is long. If the drug dose is insufficient or the course of treatment is insufficient, it can lead to poor therapeutic effect and repeated coughing up blood. Therapeutic drugs can also be combined with the use of amphotericin B, etc., focally confined persistent, recurrent invasive pulmonary aspergillosis, can be considered to do partial lung resection. 2. Whether the drug is symptomatic: Itraconazole has a certain therapeutic effect on allergic bronchopulmonary aspergillosis, and is usually ineffective for Aspergillus spherical pulmonary aspergillosis. Inappropriate choice of drugs can cause poor therapeutic effect, repeated coughing up blood. Surgery is recommended for recurrent hemoptysis in Aspergillus pulmonary aspergillosis. 3. Whether there is a new infection: If there is a new fungal or bacterial infection at the same time of treatment, recurrent coughing up of blood may also occur, and appropriate treatment should be taken according to the specific condition. It is recommended to standardize the treatment under the guidance of a doctor. The above drugs should be used under the guidance of a doctor, avoid self-medication.