Clinically, chronic obstructive pulmonary disease, bronchiectasis, and lung abscess can lead to coughing up yellow sputum in the morning. If the patient has coughing up yellow sputum in the morning, clinically, bacterial infection is considered to be more likely, and it is recommended to actively seek medical advice and improve blood routine, C-reactive protein, chest X-ray, sputum culture and other related examinations. If the patient is diagnosed with bacterial infection, antibiotics can be used for treatment. Commonly used antibiotics include cefixime, metronidazole, amoxicillin, azithromycin, levofloxacin, etc. Antibiotics can be changed according to the drug sensitivity results. If the patient has yellow sputum that cannot be easily coughed up, expectorant medications can be used. Commonly used medications include aminoglutethimide, eucalyptus citrulline enteric soft capsule, acetylcysteine, etc. If a patient develops a morning cough and coughs up yellow sputum, it is very important to actively seek medical attention and clarify the diagnosis.