The biggest difference between chickenpox and HFMD is the location of the rash. Chickenpox is an acute infectious disease caused by the varicella-zoster virus, while HFMD is an infectious disease caused by enteroviruses. The rash of HFMD is mainly located in the mouth, palms of the hands, soles of the feet, perianal area, buttocks, and the skin of the inner thighs. In contrast, chickenpox rash usually starts on the head, neck and face, and then spreads all over the trunk and limbs, and can come out all in one day, but there will be no rash on the palms of the hands and soles of the feet, which is the most important point to differentiate from HFMD. Chickenpox and hand, foot and mouth disease are both viral infections, generally symptomatic treatment, the condition is self-limiting, can improve on their own.