First, prostate cancer rectal palpation of prostate is hard as stone, uneven surface, and nodules can be touched. Serum prostate-specific antigen (PSA) is obviously elevated, and biopsy or needle aspiration cytology is needed for differentiation. Second, prostatitis acute prostatitis can occur urinary difficulties or acute urinary retention. However, patients have a sudden onset of chills and high fever, urinary frequency, urinary urgency, urinary pain. Rectal palpation of the prostate is swollen, painful, localized temperature increases, smooth surface, the formation of abscesses have a sense of fullness or fluctuation, so it can be differentiated from prostate hyperplasia. Chronic prostatitis rectal palpation prostate full enlargement, soft, mild pressure pain, long course of the prostate shrinkage hard, there are small nodules. Prostate fluid examination: leukocytes > 10 / per high power microscope field of view, lecithin bodies decreased, it is not difficult to distinguish between the two. Third, the bladder neck contracture due to chronic inflammation, the age of onset is younger, 40 ~ 50 years of age to appear symptoms. Clinical manifestations and prostatic hyperplasia are similar, but the prostate is not large, cystoscopy can be seen in the internal sphincter was a ring of narrowing, the urethra and bladder are clearly separated, the bladder neck lip is elevated into a dike, bladder neck is pale or rose color, its surface is usually smooth, lack of vascular distribution, so the two are easy to distinguish. Urethral stenosis mostly has the history of trauma or infection, and urethrography can be used for clear diagnosis. Bladder cancer near the neck of bladder can also cause bladder outlet obstruction, leading to dysuria and other symptoms, often with hematuria, which can be easily identified by cystoscopy. Neurogenic bladder dysfunction is clinically similar to prostatic hyperplasia, with difficulty in urination and urinary retention, and can also be followed by urinary tract infection, stones, hydronephrosis and renal insufficiency. However, neurogenic bladder dysfunction often has a history and signs of significant neurologic damage, and is often accompanied by sensory and motor deficits in the lower extremities, sometimes with anal sphincter relaxation and loss of reflexes. In recent years, emphasis has been placed on dysfunction of the urethral and urethral sphincters and dyspareunia caused by unstable bladder forceps. Application of urodynamic examination can be clearly identified. Seven, diabetic peripheral neuropathy can lead to dysuria, urinary retention, dribbling and other symptoms. According to the patient’s history of diabetes mellitus, the course of the disease, peripheral neuropathy reflex examination, application of urodynamic examination can be clearly identified. Eight, bladder detrusor lesions can be identified with urodynamic examination and prostatic hyperplasia.