Usually, upset stomach at meal time is considered to be related to physiological factors and pathological factors such as gastric ulcer, duodenal ulcer, Helicobacter pylori infection, gastrointestinal tumor, and so on. 1. Physiological factors: the stomach will automatically secrete gastric acid and start to digest food when it comes to meal time, if you can’t eat at this time, the secreted gastric acid will directly stimulate the gastric mucous membrane, and the symptom of gastric discomfort will appear. 2. Pathological factors: when suffering from gastric ulcer, duodenal ulcer, Helicobacter pylori infection, gastrointestinal tumors and other diseases, the gastric mucosa will be damaged, the concentration of gastric acid in the fasting time is higher, and at this time in the fasting state, the gastric acid will stimulate the lesions of the mucous membrane, which will lead to the meal to the point of the stomach discomfort, pain and other symptoms. The cause of a meal time stomach upset may also have other pathological factors, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.