The antihypertensive drugs with the least side effects actually mainly refer to the first-line antihypertensive drugs, relatively speaking, the side effects of antihypertensive drugs here are small and the effect is relatively good, such as calcium channel blockers, its representative drugs are felodipine, amlodipine. In addition, like diuretics, the representative drugs are hydrochlorothiazide tablets. Relatively speaking, its side effects are also relatively small, but it is not suitable for lowering blood pressure alone, and needs to be used in combination with other types of antihypertensive drugs, because the effect of lowering blood pressure is relatively weak. There are also angiotensin-converting enzyme inhibitors, representative drugs such as perindopril and enalapril, which can be used in combination with diuretics and calcium channel blockers, all of which can have a better effect with fewer side effects. There are also angiotensin di-receptor antagonists, such as Irbesartan and Valsartan, which can reverse left ventricular remodeling and reduce proteinuria, and are also very good antihypertensive drugs.