The cause of hypopigmentation in neurodermatitis is due to the stimulation of melanocytes in the skin by chronic inflammatory factors, which affects the activity of the cells and leads to a decrease in melanin production, resulting in the phenomenon of hypopigmentation. Neurodermatitis, also known as chronic lichen simplex, is a chronic inflammatory skin disease accompanied by obvious moss-like changes and itching symptoms. Localized hypopigmentation of the skin occurs when inflammatory factors affect the melanocytes in the skin, leading to a decrease in melanocyte production. Patients suffering from neurodermatitis should be given standardized treatment in time, so as to avoid the phenomenon of hypopigmentation, in the treatment of the main prescribed antihistamines such as loratadine, phenylephrine, and mometasone furoate cream and other glucocorticosteroids topical treatment. It is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor to standardize the treatment.