The main symptoms of late stage malignant melanoma are as follows: 1. Lymph enlargement may appear after metastasis through lymph nodes, such as the Asian population is most prone to malignant melanoma, and axillary and inguinal lymph node enlargement may appear in late stage; 2. If distant organ metastasis occurs, such as metastasis to lung, chest pain, cough, hemoptysis and other symptoms may appear. If metastasis to the liver, vague pain may appear in the liver area. If metastasis to the brain, headache, syncope and other mental disorders may appear. Therefore, malignant melanoma is a disease that spreads through lymph nodes, lymphatic fluid, and blood. If metastasis is in multiple sites, the quality of survival and survival situation of patients is not very satisfactory.