Taking entecavir to cause high bilirubin, usually need to consider the existence of their own liver injury or drug-induced liver injury causes. Entecavir is mainly used for the treatment of chronic adult hepatitis B with active viral replication or persistently elevated serum alanine aminotransferase. Entecavir may cause headache, fatigue, dizziness, and nausea in patients during its use. Also the active drug ingredient in it may cause users to experience varying degrees of liver damage, thus leading to high bilirubin, a common side effect caused by the drug. Meanwhile Entecavir treats mainly patients with hepatitis. Hepatitis patients themselves have varying degrees of liver inflammation and liver damage, which can cause elevated bilirubin during the progression and development of the disease, which is a normal complication of the disease itself. This is a normal complication of the disease itself. The elevated bilirubin usually resolves when the symptoms of hepatitis are effectively treated. If bilirubin is elevated during the period of taking Entecavir, you should go to the hospital in time to improve the biochemistry and blood tests to determine the specific cause of the disease, and then treat reasonably under the guidance of the doctor.