The cause of wheals is called needle’s eye in Chinese medicine, and there are three main causes in Chinese medicine: first, the feeling of wind-heat evil. The second point, the spleen and stomach heat. The third point is caused by the inflammation of liver fire. Clinically, for the problem of wheals, the focus should be on adjusting the function of the spleen and stomach, especially it can promote the normal conduct of the digestive system, which can make the water and grain essence and human nutrition can be better absorbed, which is also beneficial for the treatment of wheals. On the acupuncture points, we can consider the Zhong Chong point for stimulation, which can be pressed and kneaded, however, the Zhong Chong point is more painful and can also be adjusted by bloodletting. Topical western medicine can be used, including some antiseptic eye drops and the application of fire-eliminating Chinese medicines, including Niuhuang Shangqing Pills, which are effective in the treatment of wheals.