Difficulty in stomach may be related to excessive secretion of gastric acid due to chronic gastritis, gastric ulcer and gastric cancer. The symptomatic medications such as omeprazole, rabeprazole, thioglycollate and so on should be used according to the doctor’s prescription. 1. Chronic gastritis: it may be related to infection or immunity, etc., leading to chronic inflammation of the stomach, and the patient may manifest abdominal pain, abdominal distension, heartburn, acid reflux and other symptoms. Omeprazole, rabeprazole, thioglycollate, etc. can be given as prescribed by the doctor, all of which have the effect of relieving gastric discomfort. 2. Gastric ulcer: due to the gastric mucosa under the attack of high gastric acid and pepsin, there is a situation of digesting its own mucosa. Can follow the doctor’s advice to use inhibit gastric acid secretion drugs for treatment, such as omeprazole, pantoprazole, etc., inhibit gastric acid secretion after the pain will also be relieved. If there is Helicobacter pylori infection, standard anti-Helicobacter pylori treatment should be carried out, such as quadruple therapy, commonly used drugs include omeprazole, ranitidine, metronidazole, clarithromycin, bismuth pectin and so on. 3. Gastric cancer: H. pylori infection and excessive alcohol consumption may induce gastric cancer, which may cause epigastric discomfort, nausea, indigestion and other symptoms. Treat according to the doctor’s strategy. The above medicines are for reference only and specific dosage should follow the doctor’s prescription. When stomach discomfort occurs, it is recommended to consult a doctor in time, complete the relevant examination, and carry out targeted treatment or therapy under the guidance of a doctor.