In the treatment of type 2 diabetes mellitus, frequent medication changes are one of the common misconceptions. Some patients ask to change their hypoglycemic drugs when their blood sugar does not drop significantly within a short period of time after using the drugs, which is not desirable. Glucose-lowering drugs need a certain amount of time to work, and if you change your medication frequently, it will be difficult to find the right medication for you, and controlling your blood sugar will become a castle in the air. As a matter of fact, the weight of medication only accounts for 30% of blood sugar control. If patients taking oral hypoglycemic drugs have poor blood glucose control, they should first carefully analyze how their diet is controlled during this period of time, whether or not they are doing regular exercise, whether or not they are suffering from any other diseases, and whether or not there have been any major changes in their family, life and work, etc. If all of these factors are ruled out, then poor blood glucose control has the greatest likelihood to be related to the medication, and a change in the treatment regimen can be considered at this time. How do I evaluate whether a medication is appropriate? Generally speaking, the evaluation of whether a drug is suitable for a particular patient should be carried out from four aspects: First, from the evaluation of the efficacy of the drug. If this hypoglycemic drug can not make the blood glucose standard, that is, blood glucose can not be lowered to the normal range or blood glucose fluctuation is large, and can not make the glycated hemoglobin control in the normal range, even if the dose of the drug is increased to the maximum effective dose but still do not have a significant effect, you should consider switching to other hypoglycemic drugs or add. For example, in the use of sulfonylureas 1 ~ 3 years after 5% to 10% of patients with secondary failure, after treatment can be eliminated after the causative factors are still not good control of blood glucose, should be considered to add or switch to other hypoglycemic drugs. For example, patients with a long duration of diabetes may gradually lose their pancreatic islet function, and then the application of insulin secretagogues may not be effective, and should be considered to be used in combination with insulin for better control of blood glucose. Secondly, evaluation from the aspect of adverse reaction of drugs. The efficacy of a drug is no longer good, but if the adverse reaction to the patient is too large, the drug should be used with caution or not used. For example, if the patient has liver or kidney insufficiency, it is better not to use drugs such as biguanides and insulin sensitizers, and should promptly switch to other hypoglycemic drugs that have little effect on liver and kidney function. Third, consider from the aspect of patient compliance. If the patient’s adherence is not good, such as busy work or poor memory, etc. did not take the medication on time, it is difficult to control blood glucose, and still can not achieve the effect after the medication instruction to the patient, if the condition permits, we can consider switching to the glucose-lowering drug which is used less frequently every day, or the route of use and the time of use are more convenient for this patient. Fourth, according to the patient’s age, the duration of the disease to choose the appropriate drug. If the patient is older, such as more than 70 years old, sulfonylureas should be used with care and attention to the occurrence of hypoglycemia. These patients should also not use bisphosphonates, as there is a risk that it may lead to the development of lactic acidosis, and so on. Never take your own advice on medication Some patients are prone to listen to advertisements or the opinions of patients, change or add other hypoglycemic drugs on their own, so that the originally stable blood glucose fluctuations, and blood glucose fluctuations are more likely to cause complications of diabetes than hyperglycemia, worsening the condition, which is contrary to the wishes. Unauthorized use of additional hypoglycemic drugs may also have more adverse reactions, such as increasing the burden on the liver and kidneys, increasing gastrointestinal reactions, and especially increasing the risk of hypoglycemia, knowing that hypoglycemia is even more frightening than hyperglycemia, which is slow to cause harm to the body, while hypoglycemia can be instantly fatal. It can be seen that, in order to better control blood sugar and prevent complications, diabetic patients, in particular, should not change the use of glucose-lowering drugs frequently on their own. In short, diabetic patients should go to the endocrinology department for regular follow-up, and change the use of hypoglycemic drugs only under the guidance of a professional physician. Only the rational use of hypoglycemic drugs and adherence to diabetes education, dietary control, physical exercise, blood glucose monitoring go hand in hand, in order to better control blood glucose, prevent or delay the occurrence of diabetes complications.