In daily life, many parents are especially concerned about the growth and development of their children, worrying that their children suffer from certain diseases that lead to stunting, and short stature is the easiest and the most important concern for parents. Then this article explains the problems related to dwarfism.
There are many causes of dwarfism, among which growth hormone deficiency is the most common. Dwarfism caused by growth hormone deficiency is also called pituitary dwarfism or pituitary dwarfism. Various causes of pituitary gland injury and tumors can cause insufficient secretion of growth hormone, leading to the development of dwarfism.
What are the diagnostic criteria for growth hormone deficiency dwarfism?
The following diagnostic criteria are clinically accepted: 1. Height growth <4cm/year. 2. Bone age is more than 2 years behind the normal average value for the same age and sex. 3. Most of them are combined with abnormal or delayed development of secondary sexual characteristics. 4.The blood growth hormone index is less than 10ug/L in three growth hormone stimulation tests (L-dopa, colistin and GnRH). 5.Exclude other causes of short stature. Which children are suitable for recombinant human growth hormone treatment? 1.Height growth rate <4cm/year. 2.Bone age delay >2 years.
3.The results of growth hormone stimulation test (twice) indicate that the peak GH is <5ug/L. What are the indicators of recombinant human growth hormone treatment? After the application of recombinant human growth hormone treatment, what kind of indicators indicate that the treatment is effective? It is generally believed that in the first year of treatment, the growth rate of 8-15cm is the normal growth rate; in the second year, the growth rate slows down, but is still faster than the normal growth rate; in the third year, the growth rate is basically similar to that of normal people. Adverse effects of recombinant human growth hormone 1. It may lead to abnormal glucose metabolism and even develop into diabetes. 2. Rapid growth of epiphysis and increase in body hair may cause dislocation of epiphysis or slippage of femoral head, resulting in lameness or pain in hip and knee. 3.Growth hormone can promote cell mitosis, leading to an increase in the prevalence of leukemia.