Rheumatoid arthritis may recur with immunosuppression. Rheumatoid arthritis is a chronic systemic disease with inflammatory synovitis as the main cause, there is no clear and effective cure for this disease, the current treatment is based on medication, supplemented by surgical treatment, the purpose of treatment is to slow down the progression of the patient’s condition and improve the patient’s quality of life, immunosuppressant is one of the commonly used types of drugs in the drug treatment. Immunosuppressants are one of the common types of medications used in the treatment of rheumatoid arthritis. Common immunosuppressants are methotrexate, salicylazosulfapyridine, and azathioprine, etc. Some patients can achieve clinical remission after active treatment, but there is a possibility of relapse after clinical remission is achieved by using immunosuppressants. Rheumatoid arthritis patients are advised to go to the rheumatology and immunology department of a regular hospital for detailed consultation, take medication as prescribed by the doctor, and test the relevant indexes on a regular basis.