The urethral orifice burning pain may be caused by urinary tract infections, urinary stones, prostatitis and other diseases, it is recommended that patients promptly consult a doctor to clarify the cause under the guidance of the doctor for targeted treatment. The actual UTIs are the best way to get the most out of the UTIs. Urinary tract infection is generally based on bacterial infection, the common causative agent is Escherichia coli, can be treated with cefaclor, levofloxacin and other antibacterial drugs as prescribed by the doctor, should also drink more water, more urination; 2, urinary stones: urinary stones block the urethral orifice, or relatively sharp stones scratch the mucosa of the urethral orifice, will cause burning pain in the urethral orifice, patients also have abdominal pain, urinary frequency, urinary urgency, urinary difficulties, and even hematuria and other symptoms. Even hematuria and other symptoms. Patients should drink a lot of water to produce a large amount of urine to help the stones to be flushed out of the body. If the stones are large and difficult to discharge through conservative treatment, they can be treated with methods such as extracorporeal ultrasonic lithotripsy; 3. Prostatitis: Mostly caused by bacterial infection, the inflammation can spread to the urethra and cause urethritis, and the inflammation can cause burning pain at the urethral orifice. The actual fact is that you can use antibiotics such as oxyfloxacin and amoxicillin for treatment, and if you form a prostate abscess, you also need to undergo surgical incision and drainage.