Back pain in the middle of the night can be caused by the following reasons: first, gallbladder disease, when there is cholecystitis or gallbladder stones can appear acute attacks, resulting in the right side of the back pain in the middle of the night, then we should check the ultrasound, CT and blood tests of the gallbladder to diagnose and treat. Second, heart disease, when the heart has angina pectoris or heart attack, the pain on the left side of the back can also appear radiologically, then it is necessary to check the ultrasound, imaging, electrocardiogram and blood tests of the heart for early diagnosis and treatment. Third, intercostal neuralgia, intercostal neuralgia can also lead to acute attacks in the middle of the night and lead to back pain, which can be investigated and examined early and treated with nerve nutrition and closure therapy early.