Itching all over the body in the middle of the night is a condition that can be caused by an acute allergic reaction, most commonly by the presence of acute hives. This is because most of this disease may be due to allergic factors that cause itching all over the body, accompanied by some obvious rash, such as the emergence of generalized wind. At this time, timely antipruritic treatment is needed, and appropriate oral antihistamines can be taken to stop the itching. Generally, you can take oral levocetirizine hydrochloride, paracetamol, or oral ketotifen, cyproheptadine, etc., which can effectively stop the itching. You can also apply topical glyburide lotion to relieve the itch. If the itching continues to worsen, intramuscular injection of antihistamines, such as Benadryl, may also be required. In addition, intravenous corticosteroids can be given to relieve itching and anti-inflammatory treatment, such as intravenous dexamethasone or hydrocortisone.