Swollen hands at night wrist and ankle pain may be caused by rheumatoid arthritis, gout, trauma. 1. Rheumatoid arthritis: rheumatoid arthritis is an immune disease, low resistance in the elderly, immune system disorders can lead to the onset of arthritis. In addition to the swelling of the hands at night wrist and ankle pain, there may be the phenomenon of morning stiffness, resulting in patients waking up in the morning when the fingers feel stiff and unable to move. 2. Gout: gout is a metabolic disease, purine and uric acid content is too high, due to a series of biochemical reactions, the generation of exudate will form the end of the joint deformity of the fingers, bulging, resulting in patients with night hand swelling wrist ankle pain. 3. Trauma: If the patient is subjected to violent trauma may cause soft tissue contusion, often accompanied by localized swelling, bruising and localized pressure pain, resulting in hand swelling wrist ankle pain. In severe cases, even motor dysfunction occurs, activities are limited. There are many other causes of hand swelling wrist ankle pain at night, such as nephrogenic edema, cardiogenic edema combined with joint inflammation, etc. If you can’t get relief in time, please go to the hospital in time, so as not to miss the condition.