High-grade squamous intraepithelial neoplasia generally refers to the occurrence of high-grade squamous intraepithelial neoplasia of the cervix, which is more serious and may further develop into cervical cancer if not actively treated. High-level squamous intraepithelial neoplasia of the cervix is a pathological diagnosis, mostly related to human papilloma virus infection, resulting in cervical squamous epithelial cells have undergone anomalous hyperplasia. Some patients may have vaginal discharge, leukorrhea and other discomforts, but the symptoms are mostly non-specific. For patients with high-grade squamous intraepithelial neoplasia of the uterine cervix, active treatment can be carried out through cervical LEEP surgery or cold-knife conization to remove localized diseased tissues, and should not be allowed to continue to develop, or the disease will progress to cervical cancer, which will affect the quality of life. For patients who are found to have high-grade squamous intraepithelial neoplasia, it is recommended that they go to the gynecology department of regular hospitals for consultation and active treatment under the guidance of doctors.