The day before yesterday, a young mother who was a repeat hepatitis B carrier, with a major triplet and HBV DNA 7log IU/ml, came to the clinic to consult about her baby. 1.5 years ago, when she was 5 months pregnant, she also had such a high viral load, and at that time she was advised to consider taking tebivudine for mother-to-child blockade when she was 7 months pregnant, but she was worried about the adverse effects of the drug and firmly refused, successively after After several conversations and also after 2 months of consideration, she finally chose not to take the medication. After all, if you don’t use antiviral drugs in late pregnancy, your baby won’t be infected. Even if you use antiviral drugs, there is a 0.7%-2% chance that the blockade will fail, and the safety of the drugs to the fetus, the side effects of the drugs, and whether the mother will rebound or have viral resistance if she stops taking the drugs later are also things to consider, so I couldn’t persuade her to definitely use the drugs to block. After the baby was born, she was vaccinated with hepatitis B vaccine and hepatitis B immunoglobulin, and regarding the feeding method, she chose to hand-feed. Now that the baby is one year old, she came to consult me if the baby will have antibodies? I suggested her to have her baby checked for hepatitis B five, and at first she was reluctant, saying that infection was not very likely, right? She was reluctant at first, saying that it was unlikely to be infected, that the baby was too young, that it was inappropriate to draw blood, etc. I said that I also hoped that my baby was not infected and that I had to have the test results to be sure. The young father came into the clinic and told me that the child’s mother did not dare to come to see me, and when he was talking his hands were shaking and he was very nervous. At that time, I had an inexplicable sadness in my heart. In fact, the young mother was afraid to face herself. Now I can’t say anything, especially “what if it had been earlier” and so on, which adds to their psychological burden. I told him that most people infected with the hepatitis B virus do not necessarily develop the disease, but are only a state of virus carriage, and a few people will also occur spontaneous clearance, early detection and early detection is a kind of protection for the baby, and hepatitis B is treatable and controllable, not so terrible. I can’t say that the mother’s choice was wrong. For mothers with high viral replication, the use of hepatitis B vaccine and immunoglobulin after the birth of the baby has an 80% success rate of blockage, and there is also the possibility of infection already occurring in the early and middle stages of pregnancy. I am speaking out about this matter just to express the view that there are indeed uncertainties regarding mother-to-child blockade of hepatitis B in women of childbearing age, such as safety for the baby and the mother, recurrence of the virus after stopping the medication or even abnormal liver function that was normal, side effects of the medication, etc., which need to be weighed against the pros and cons. Over the past few years, different studies by hepatologists and obstetricians and gynecologists in Beijing and Nanjing have led to an enrichment of practical experience, especially with the introduction of the Expert Consensus on the Management of Fertility in Women with Hepatitis B Virus Infection, which has led to more standardized treatment. However, expert consensus is not a legal instrument, and practical experience is not equivalent to trial results, there are also ethical issues involved, so consent of patients and families must be required regardless of the modality. On the basis of mutual understanding and cooperation between doctors and patients, it is our common goal to do a good job of mother-to-child interruption of hepatitis B.