Mifepristone, also known as “pearl stop”, is a 25mg tablet with strong binding ability to progesterone receptors and has anti-progesterone and anti-glucocorticoid effects. The main clinical applications are as follows: 1. Mifepristone is used in combination with misoprostol to terminate early pregnancy, and the effect is more satisfactory; 2. In the treatment of endometriosis, mifepristone has a strong affinity with progesterone receptors on the surface of the uterus, which is about five times that of progesterone, and can lead to amenorrhea, thus causing atrophy of endometriotic lesions; 3. Mifepristone is used in combination with methotrexate for the conservative treatment of ectopic pregnancy, and the effect is also more satisfactory ; 4, treatment of uterine fibroids. Contraindications to the use of mifepristone are as follows. Contraindications to the use of mifepristone include patients treated with long-term cortisone, patients with abnormal bleeding, and those with heart, liver, and kidney disease and renal insufficiency.