The most common cause of a blister in the vagina is due to a cyst in the vaginal wall. In this case, surgery is needed. It is best to have a routine test of the leukocytes 3-7 days after menstruation without intercourse. If there is no inflammation in the leukocytes and if the blood count and clotting time are normal, the cyst can be removed and the wound can be closed. After the operation, keep the vulva clean, it is recommended to scrub the vulva with iodophor twice a day. It is recommended not to eat spicy and acidic food in order to facilitate the healing of the local wound. In the case of blisters at the vaginal opening, it is important to differentiate whether they are caused by herpes simplex virus infection. These blisters tend to be small and intensely itchy, with severe pain when they rupture, and can be treated with acyclovir ointment.